Protein_Domain
p28

Part:BBa_K320016

Designed by: Perrudet Christian   Group: iGEM10_EPF_Lausanne   (2010-10-18)

p28

This BioBrick contains the protein P28.

The ookinete (Plasmodium stage in mosquito's gut) has been intensively studied by scientists, looking for an ideal transmission-blocking vaccine target. IGEM EPFL team's was interested in the ookinete surface membrane proteins Pfs25 and Pfs28 (link to other biobrick). It has been shown that the binding of specific antibodies to these surface proteins was fatal to more than 99% of the ookinetes. Indeed, P25 and P28 seem to be essential for the ookinete to be able to cross the midgut epithelium and thereafter transform into an oocyst.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None